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Best Career Comebacks

10 of 26

Patrick Dempsey

Who knew that the scrawny young star of '80s teen films ("Loverboy," "Can't Buy Me Love") would turn into such a hunk? Dempsey disappeared from the public eye after these early successes, but has made it to the A List as McDreamy on "Grey's Anatomy." (Photo by Stephen Lovekin/Getty Images)

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