The Arquette brood is one of Tinseltown's largest dynasties, and representing the female side of the family are sisters Patricia and Rosanna. Rosanna, 56, has appeared in a myriad of television and movie roles, including recent spots on "Ray Donovan" and the movie "Draft Day." Patricia, 47, played the lead role on the television series "Medium" from 2005-2011. She recently earned an Academy Award for her performance in "Boyhood." —XFINITY Entertainment Staff (Photo by Kevin Winter/Getty Images)
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