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Top 40 Over 40 Celebs

3 of 41

#38: Patricia Arquette

We'd like to know the psychic secret behind former "Medium" star Patricia Arquette's immaculate skin. The actress turned 42 on April 8, 2010. (Photo by Alberto E. Rodriguez/Getty Images)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.

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