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MTV Stars Then & Now

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Karen Duffy

Then: The model and TV actor joined MTV in the early '90s and made an instant impression as the precocious "Duff."

Now: Following a bout with sarcoidosis of the central nervous system, for which she underwent chemotherapy, Duffy released a well-received autobiography, "Model Patient: My Life As an Incurable Wise-Ass," and returned to TV. In 2009, she provided the voice of Linda Otter in "Fantastic Mr. Fox." —XFINITY Entertainment Staff (Photos: George De Sota, Bryan Bedder/Getty Images)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.

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