After a mix of television roles on shows such as "Greg the Bunny," and bit parts in movies such as "There's Something About Mary," Sarah Silverman hit her stride in the late 2000s. She starred on the Comedy Central show "The Sarah Silverman Program" for three years and was asked to host the MTV Movie Awards in 2007. The 45-year-old actress most recently tackled a dramatic role in the series "Masters of Sex," and provided the voice of Vanellope von Schweetz in "Wreck-It Ralph." —XFINITY Entertainment Staff (Photo: Jason Merritt/Getty Images)
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