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20 Greatest Sitcom Characters of All Time

4 of 22

18. Niles Crane (David Hyde Pierce), 'Frasier'

Dr. Niles Crane is a Seattle-area psychiatrist and brother to famed KACL radio psychiatrist, Dr. Frasier Crane. Niles is obsessive compulsive, occasionally neurotic, often snobby and highly intellectual. For years, Niles lusted after his father's live-in physical therapist, Daphne Moon. The two eventually married.

David Hyde Pierce played Niles from 1993-2004.—XFINITY Entertainment Staff (Photo: AP/NBC)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.

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