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Elavil, Endep, Vanatrip (Amitriptyline)

Tricyclic antidepressants (TCAs), such as amitriptyline, are linked to weight gain more than other antidepressants or migraine meds.

TCAs affect neurotransmitters involved in energy and appetite, such as serotonin, dopamine, and acetylcholine, but their antihistamine activity is probably the reason for weight changes, Roerig says.

These drugs are given less often for depression because an overdose can damage the heart. Lower doses can prevent migraines, but a 2006 study found that 30% of people taking amitriptyline for migraines gained more than 5% of their body weight in 26 weeks.

(Photo Credit: Getty Images/Text: Carina Storrs)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.

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